Endocrine Abstracts

Aim: To define the main predictors of metabolic control in children and adolescents and evaluate its improvement along the years.Methods: We included children and adolescents with 1DM, with more than two years of disease. Data were collected at 2005 and at 2012. Sex, age and severity at diagnosis, therapy in the last year, age at onset of multiple daily insulin injections (MDII) and continuous subcutaneous insulin infusion (CSII), number of group educati...

Objective: Familial combined hyperlipidemia (FCH) is the most common familial hyperlipidemia with a high risk of the early atherosclerosis. The aim of this study was to compare levels of s-ICAM-1 and s-VCAM-1 in asymptomatic members of FCH families with healthy controls and to find out relation between s-ICAM-1, respective s-VCAM-1, and risk factors accompanying FCH. We also investigate association between adhesion molecules and intima-media thickness of common carotid artery ...

Craniofacial proportions of girls with TS, compared to normal children, show reduced size of the craniofacial complex, retrognathic profile and tendency towards advanced dental age. Growth hormone (GH) treatment in TS positively affects stature, but its effects on craniofacial growth and dental development are largely unknown. The aim of this study was to analyze and to correlate the craniofacial morphology, chronological, dental and bone ages of TS patients receiving GH or no...

Growth is a complex process, influenced to a large extent by GH. Children with GH deficiency (GHD) have typical somatic features, including short stature and a reduction of the craniofacial structures. Dental age (DA) is normally delayed in relation to chronological age (CA). The effect of GH replacement on craniofacial growth is still poorly understood. We studied the craniofacial development and dental maturation in 17 patients (4F, 13M) with GHD of different etiologies. The...

Background and aims: Thyroid nodular disease (TND) is a common condition in the general population. Malignant nodules occur in 5% of patients with thyroid nodules. Fine-needle aspiration biopsy (FNAB) is considered to be the most reliable method of differentiating benign and malignant thyroid nodules. The purpose of this study was to assess the accuracy of FNABs performed in our Hospital.Methods: We retrospectively reviewed the medical records of patient...

The 250 mg short synacthen test (SST) is the most commonly used tool to assess the integrity of hypothalamic-pituitary-adrenal (HPA) axis. There are many instances when compromise to HPA-axis function is potentially reversible (including the use of suppressive dose of prescribed glucocorticoids), but currently there are no data to guide clinicians as to the frequency of repeat testing or to the likelihood of HPA-axis recovery. We performed an observational, retrospective, anal...

Background: Bariatric surgery is known to dramatically increase insulin sensitivity in severely obese adults. However quantifying insulin sensitivity in these patients with methods such as the hyperinsulinaemic euglycaemic clamp is technically challenging. The leptin to adiponectin ratio (LAR) has previously been validated as a measure of whole body insulin sensitivity. Leptin is a known mediator of metabolic and cardiovascular complications of obesity. Adiponectin has anti-at...

BackgroundSomatostatin analogues (SSA) (octreotide and lanreotide) are recommended as a first line treatment of locally advanced or metastatic well-differentiated neuroendocrine tumors (NETs) with a good expression of somatostatin receptor (SSTR). Both of them are usually used in injection repeated every 4 weeks.The study objectiveWas to compare the way of SSA administration (injection performed by profession...

IntroductionKetosis-Prone Diabetes (KPD) is a heterogeneous condition that shares clinical characteristics of type 1 and type 2 diabetes. It is usually a challenging diagnosis because patients are prone to develop diabetic ketoacidosis (DKA) without having the classic clinical phenotype of autoimmune type 1 diabetes.Case reportA Caucasian 26-years-old female with known history of renal transplant, morbid obes...

Insulinomas are rare insulin-producing pancreatic neuroendocrine tumours. Most insulinomas are non-metastatic and can be cured by surgery, but in 10% of the patients insulinomas metastasize, which is associated with a significantly impaired overall survival. As the metastatic potential of an insulinoma cannot be reliably predicted with the current biomarkers, we aimed to evaluate the expression of somatostatin receptors (SSTRs) and glucagon-like peptide-1 receptors (GLP-1Rs) i...